Zembrin is a patented extract of Sceletium tortuosum – a succulent plant commonly found in South Africa, also known as Kanna. Fermented Sceletium root was traditionally chewed in South Africa to relieve stress and anxiety and elevate mood.
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Kanna is a natural mood booster. Sceletium tortuosum contains mesembrine – an alkaloid that is known for its action on the nervous system. In most people, it causes a feeling of euphoria and decreases anxiety, depression, tension, and even appetite. The preparations made with this plant are often used to treat depression and psychological or psychiatric disorders.
Mesembrine and the Sceletium tortuosum extract might be used as natural antidepressants. Clinical research has shown that people reported better sleep and lower stress levels after taking Sceletium tortuosum (such as Zembrin - the most commonly available extract). When used in rat studies, the purified Sceletium tortuosum extract was approximately two times less effective than imipramine, a tricyclic antidepressant.
Cell studies have shown that rich in mesembrine Sceletium tortuosum extract reduces levels of the stress hormone cortisol. Researchers suggested that the extract might benefit people with increased stress and blood pressure.